New manuscript out in Immunity!

Mechanisms that support long-term autoimmune CD4 T cell persistence and function are still unresolved. Aljobaily et al. demonstrate that epigenetic programing of autoimmune CD4 T cells allows fine-tuning of TCF1 transcription factor activity to balance survival and effector function. https://www.cell.com/immunity/abstract/S1074-7613(24)00479-5